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HAMBURG, Germany — First they pointed a finger at Spanish cucumbers. Then they cast suspicion on sprouts from Germany. Now German officials appear dumbfounded as to the source of the deadliest E. coli outbreak in modern history, and one U.S. expert called the investigation a "disaster." Backtracking for the second time in a week, officials Monday said preliminary tests have found no evidence that vegetable sprouts from an organic farm in northern Germany were to blame. The surprise U-turn came only a day after the same state agency, Lower Saxony's agriculture ministry, held a news conference to announce that the sprouts appeared to be the culprit in the outbreak that has killed 22 people and sickened more than 2,330 others across Europe, most of them in Germany, over the past month. Andreas Hensel, head of Germany's Federal Institute for Risk Assessment, warned, "We have to be clear on this: Maybe we won't be able anymore to identify the source." At an EU health ministers meeting Monday in Luxembourg, Germany defended itself against accusations it had acted prematurely in pointing to Spanish cucumbers. "The virus is so aggressive that we had to check every track," said Health State Secretary Annette Widmann-Mauz. The EU will hold an emergency meeting of farm ministers Tuesday to address the crisis, including a ban imposed by Russia on all EU vegetables.